Common anticholinergic drugs like Benadryl linked to increased dementia risk … A report published in JAMA Internal Medicine several years ago … 2015 Occasional Benadryl® use does not appear to meaningfully increase dementia risk based on current evidence. The research raising concern focuses … People with Alzheimer\’s should avoid Benadryl and other medications that contain diphenhydramine when possible. These medications may aggravate … 2025 Current research has yet to link Benadryl® use to the risk of developing dementia. Because Benadryl® belongs to a class of medications which shows possible link … Does Benadryl cause dementia? Research hasn\’t proven a direct link, but its drug class is associated with risk. Learn precautions to use it safely. Taken together, the study doesn\’t suggest that occasional or short-term use of Benadryl (or other anticholinergics) increases the risk of … An observational study of older hospitalized patients reported that diphenhydramine treatment significantly increased risk for delirium symptoms … 2015 The studies indicate that the dementia risk increases with high cumulative doses and extended use. For example, consistent use of Benadryl over … There may be a connection between using diphenhydramine and an increased risk of Alzheimer\’s disease. The possibility of a relationship between … Studies show possible links between long-term use of anticholinergic medications and dementia. Other treatment options may be preferred. Long-term use of Benadryl has been associated with increased dementia risk, but more research is needed. Researchers saw an increased risk of dementia in the people who were on anticholinergic drugs, including Benadryl. Deciding what to do with this … A 2015 study, led by a researcher from the University of Washington, found that people who take Benadryl regularly are more likely to develop dementia as they … Researchers have suggested these drugs might affect inflammation and blood flow in the brain, which may result in memory loss and weakened … Research indicates that anticholinergic properties in certain antihistamines may contribute to cognitive decline and increase the risk of … For example, diphenhydramine (Benadryl) has strong anticholinergic activity. But current research isn\’t clear on whether it increases your risk of dementia. Studies show possible links between long-term use of anticholinergic medications and dementia. Other treatment options may be preferred. Benadryl certainly can cause cognitive issues, especially in elderly people, but the study that is used to try to associate it with developing … Higher dosage or long-term use of common drugs with anticholinergic effects is linked to significantly increased risk of dementia … Could older adults using anticholinergic drugs such as non-prescription sleep aids and the antihistamine Benadryl be at greater risk of developing dementia … Over time, anticholinergic drugs, especially antihistamines like Benadryl, increased the development of dementia, including Alzheimer\’s. A study … It is the first study to show a dose response: linking more risk for developing dementia to higher use of anticholinergic medications. And it is … 2013 Benadryl (diphenhydramine) has been linked to an increased risk of dementia, particularly with long-term or high-dose use in older adults, …