The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including CYMBALTA, alone but particularly with … CYMBALTA® (duloxetine hydrochloride) is indicated in adults for: • Major Depressive Disorder. CYMBALTA is indicated for the symptomatic … 4.2 Dosierung und Art der Anwendung. Dosierung. Depressive Erkrankungen: Die Startdosis sowie die empfohlene Erhal- tungsdosis betragen 60 mg einmal täglich …